A forced degradation study of acebutolol hydrochloride in bulk and injectable form was conducted under hydrolytic condition. The study was conducted as per available guidelines and main references. Stability indicating RP- HPLC method has been reported for analysis of acebutolol hydrochloride. Purposeful degradation can be a useful tool to predict the stability of a drug substance or a drug product with effects on purity, potency and safety. Acebutolol hydrochloride is a cardio-selective beta-blocker used in the management of hypertension, angina pectoris and cardiac arrhythmias. Extensive degradation was observed under hydrolytic condition using acid, alkali and oxidative hydrolysis. The degraded products were analysed by standard comparison method of UV spectrophotometry. Forced degradation was performed in bulk drug and tablet dosage form using 1 N sodium hydroxide, 0.1 N hydrochloric acid and 6% H2O2. 25.46% and 23.54% degradation was observed after 90 mins using alkali hydrolysis in 0.1 N sodium hydroxide, 20.56% and 20.68% degradation was observed at the end of 90 minutes in 0.1 hydrochloric acid, 23.68% and 23.51% degradation was observed after 90 mins using 6% H2O2 in bulk content and sample content respectively. It was concluded that acebutolol hydrochloride was found unstable under acid, alkali and oxidative hydrolysis conditions.
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